Molecular Microbiology and Human Diseases

Biological Sciences

Molecular Microbiology and Human Diseases

For a disease free nation.

Research Focus

Our work bridges the fields of Molecular Biology and Microbiology to safeguard the ecosystem. By identifying serum biomarkers, we enable early, low-cost diagnostics for latent tuberculosis before active transmission occurs. Simultaneously, we provide definitive molecular evidence by mapping how climate variability alters airborne microbiomes and triggers respiratory disease burdens. We also study how microplastics act as vectors for the spread of antimicrobial resistance in air and water. 

We employ advanced laboratory techniques, including real-time PCR, metagenomics, Sanger sequencing, RAMAN spectroscopy, bioinformatics tools etc. Our project takes part in many multidisciplinary research ventures of national importance, serving the best with the existing laboratory facilities.

Why does this matter?

Microbes dictate the delicate balance of our environment and the human body. While most microorganisms are beneficial, disrupting this equilibrium can lead to severe public health crises that strain Sri Lanka’s free healthcare system.

Whether we are studying gene expression in the serum of patients with latent tuberculosis, tracing how emerging pollutants like microplastics act as environmental "hotspots" for antimicrobial resistance, or understanding how airborne bacterial communities affect respiratory health, our research transforms complex laboratory insights into actionable national frameworks. This data is critical for national policymakers to restructure urban air quality standards, optimize municipal waste management, combat antimicrobial resistance and other health crises, directly easing the country's economic and healthcare burdens. 

Projects

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Project 01: Transcriptome Analysis of Serum of Latent Tuberculosis Patients for Candidate Biomarker Identification.

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Project 02: Molecular characterization of the airborne bacterial community and assessment of the correlation with respiratory disease incidence in Kandy city, Sri Lanka

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Project 03: Molecular characterization of Microplastic-Associated Bacteria and the spread of Antimicrobial Resistance genes in Kandy Lake.

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Project 04: Identification of airborne bacteria, airborne microplastic and antibiotic resistance genes at Gohagoda dumping site, Kandy, Sri Lanka

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Genetic Characterisation of Drug-Resistant Mycobacterium tuberculosis Isolates from Sri Lankan and Pakistani Tuberculosis Patients and Identification of Associated Biomarkers

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Diversity and Distribution of Thermophilic Microorganisms in Hot Springs of Sri Lanka: A Metagenomics Approach

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Epidemiological Study on Asbestos Related Occupational Health Problems Among Asbestos Industry Workers in Sri Lanka

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Transcriptome Analysis of Mycobacteria in Serum Exosomes of Latent Tuberculosis Patients For Candidate Biomarker Identification

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Enrichment Mechanisms of CKDu-Risk Factors in Ground Waters, Their Uptake Pathways and Potential Remedies

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Identification of Urinary Biomarkers For CKDu and Diabetic and Hypertensive CKD in Sri Lanka

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Determining Cyanotoxin Releasing Mechanisms of Freshwater Cyanobacteria

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Characterisation of Antibiotic Resistomes in Selected Geothermal Springs in Sri Lanka

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Balloon Flights Over Central Sri Lanka to Detect Possible Ingress of Cometary Microorganisms & Particulate Matter

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Lab Members

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Samangi De Silva

Samangi De Silva

Research Assistant

Molecular Microbiology and Human Diseases
Hiruni Jayanetti

Hiruni Jayanetti

Research Assistant

Molecular Microbiology and Human Diseases
Lahiru Wickramasinghe

Lahiru Wickramasinghe

Research Assistant

Molecular Microbiology and Human Diseases

Research and Dissemination Outputs

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